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Grape Antioxidants for Heart Health and Diabetes

April 29, 2009 Written by JP       [Font too small?]

Grapes are one of the most scientifically studied foods in the modern diet. Researchers tend to focus on grape seed and grape skin extracts, but juice and red wine frequently get attention as well. The reason for so much interest is that this richly pigmented fruit is chock full of powerful antioxidants and phytochemicals that are known to promote good health. Today’s blog presents an update of the most current findings on these nutritional superstars.

Inside Grape Seeds

New research from the University of Michigan Cardiovascular Center suggests that grape powder may protect the cardiovascular system. (1) Researchers specifically looked at the impact that grapes would have on a group of salt-sensitive, hypertensive rats.

In this study, the rats were provided with either a grape powder or a low dose of a “common blood pressure drug” (hydrazine) for a period of 18 weeks. The grape powder was a mixture of green, red and black grapes and made up 3% of their overall diet. The two sets of rats were fed a high salt diet.

Both groups demonstrated a reduction in blood pressure. But, a significant difference was found between the two treatments: the rats receiving the grape blend also showed signs of better heart function and a decrease in heart muscle damage. Based on diet alone, there was an expectation that the high-salt content would cause heart damage to all of the rats.

The scientists involved believe that the naturally occurring antioxidants in grapes may activate a “protective process in the genes that reduces damage to the heart”.

Two additional studies (2,3) from March 2009 suggest that other mechanisms may also be involved. The first points to the benefits of flavonoids (found in grapes) in promoting elasticity of arteries and, thereby, improving circulation. This allows for greater glucose and oxygen delivery and the “removal of waste products”. Chronic inflammation is now considered a contributing factor in many health concerns, including cardiovascular disease. A recent experiment found that grape seed extract could counter inflammation brought about by an unhealthy diet.

Grape Are Rich in Polyphenols

Grapes have long been associated with heart health. But, there are other seemingly unrelated conditions that also respond to grapes and grape extracts. Here’s a brief overview of a fraction of the potential of this powerful fruit:

  • Alzheimer’s Disease and Brain Health: Oxidative damage is thought to play an important role in neurodegenerative diseases such as Alzheimer’s disease, Parkinson’s disease and stroke. (4) Antioxidants may prevent such damage, but only if they can cross the “blood brain barrier”. Grape seed extract does just that. (5) This may be part of the reason why evidence points to its role in limiting the build up of Amyloid-beta plaque and inflammation in a mouse model of Alzheimer’s. (6) Both of these processes are considered central to the progression of this debilitating disease. Another recent trial concluded that grape antioxidants could help protect the brain from accelerated cell death in mice with Alzheimer’s disease. (7)
  • Cancer: Many forms of cancer appear to be sensitive to the effects of grape extracts (GE). In the past few months research has emerged showing that GE may help combat breast cancer and its spread to other parts of the body (“metastasis”). (8) A study in January 2009 reported that GE protects against skin cancer and the related inflammation that may play a role in other forms of cancer. (9) That same month, GE was found to decrease the growth and increase the rate of cell death in certain human colorectal cancer cells. (10) Another interesting experiment from February 2009 discovered that both grape skins and seeds had an anti-H. pylori effect. H. pylori is associated with a greater risk of gastric cancer. (11)
  • Diabetes: A paper published in the January issue of Phytotherapy Research describes grape seed extract’s ability to lower blood sugar, both in the short term and over longer periods of time, as measured by HbA1c levels. (12) A Chinese study, also from 2009, noted that grape seed extract helps to reduce diabetic related damage to kidneys, lowers blood pressure and counters the progression of diabetic neuropathy (nerve damage). (13)

I think we’ll continue to see an abundance of research on grapes in the near and distant future. It seems that the more we learn about them, the more promising a natural remedy they become. All you have to do is decide which form is right for you – the whole fruit (with seeds), the juice, nutritional supplements or wine.

Be well!


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5 Comments to “Grape Antioxidants for Heart Health and Diabetes”

  1. Robin Thomas Says:

    Thank you for another well researched and written article. I have been very interested in the role of grape extracts in all forms, and have been following the research of the Linus Pauling Institute on resveratrol http://lpi.oregonstate.edu/infocenter/phytochemicals/resveratrol/index.html

    What is your opinion on the relative benefits of resveratrol from red wine vs a tableted supplement?

  2. JP Says:

    Good day, Robin. Thank you for your kind comment!

    My basic position on resveratrol is that in order to get the amounts used in the clinical studies (mostly conducted in an animal model) you’d have to use a concentrated supplement version of this phytochemical.

    Having said that, red wine contains many other health promoting substances besides resveratrol. Those other phytochemicals may promote wellness independently but they may also act synergistically with the naturally occurring resveratrol in red wine.

    Here’s the approach I’m personally taking at the moment: When I drink alcohol, I only drink red wine – preferably organic or biodynamic varieties (that are sulfite-free and possibly higher in resveratrol).

    I also use a red wine supplement that is standardized to contain 3 mg of resveratrol (exclusively from grapes) per capsule three times a day. This is the equivalent of many glasses of red wine – more than I could possibly drink.

    I’m currently in my 30s so I feel as though this dosage is probably adequate. For more intensive anti-aging effects, a higher dosage might be necessary.

    I think there will be many more studies published in the next couple of years that will help clarify what type of dosage range would be most appropriate.

    Be well!


  3. krishibid durlave roy Says:

    where there is life there is hope
    -krishibid durlave roy

  4. JP Says:


    Be well!


  5. Gil Harnois Says:

    Polyphenolics’ MegaNatural-BP Grape Seed Extracts have been in the spotlight recently. Looks like they have gotten an Award from Frost & Sullivan, a leading analyst and market research firm. See link here: http://www.nutritionhorizon.com/news/Polyphenolics-Earns-Frost-Sullivan-Award-for-its-MegaNatural-BP-Grape-Seed-Extract.html

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