Comments on: DIM – Diindolylmethane http://www.healthyfellow.com/427/dim-diindolylmethane/ Your Natural Health Critic Thu, 09 Feb 2012 18:34:21 +0000 hourly 1 http://wordpress.org/?v=3.0.4 By: JP http://www.healthyfellow.com/427/dim-diindolylmethane/comment-page-1/#comment-1945 JP Mon, 14 Dec 2009 07:06:52 +0000 http://www.healthyfellow.com/?p=427#comment-1945 Excellent points, Bill. Thank you for sharing that! :) Be well! JP Excellent points, Bill. Thank you for sharing that! :)

Be well!

JP

]]> By: Bill Rawls http://www.healthyfellow.com/427/dim-diindolylmethane/comment-page-1/#comment-1941 Bill Rawls Mon, 14 Dec 2009 03:35:13 +0000 http://www.healthyfellow.com/?p=427#comment-1941 Great article, JP. The effect is real. I have known several patients who were able to reverse dysplasia with high intake of cruciferous vegetables. I usually tell them to add in green tea and regular consumption of berries to their daily diet also. It should be noted, however, that glucosinolates are toxic to thyroid and liver tissue. This does not appear to be a pronounced effect, but individuals suffering from thyroid disease or liver disease should take note. It may be that indole-3-carbinol and DIM are less toxic than other glucosinolates, but I have not been able to find enough evidence to say for sure. If this were the case, supplements would be superior to diet. Either way, it appears benefits outweigh the risks for most people. I recommend a routine check of liver and thyroid function at yearly exams for those eating higher than average amounts of cruciferous vegetables or taking supplements. Great article, JP. The effect is real. I have known several patients who were able to reverse dysplasia with high intake of cruciferous vegetables. I usually tell them to add in green tea and regular consumption of berries to their daily diet also.

It should be noted, however, that glucosinolates are toxic to thyroid and liver tissue. This does not appear to be a pronounced effect, but individuals suffering from thyroid disease or liver disease should take note. It may be that indole-3-carbinol and DIM are less toxic than other glucosinolates, but I have not been able to find enough evidence to say for sure. If this were the case, supplements would be superior to diet.

Either way, it appears benefits outweigh the risks for most people. I recommend a routine check of liver and thyroid function at yearly exams for those eating higher than average amounts of cruciferous vegetables or taking supplements.

]]> By: JP http://www.healthyfellow.com/427/dim-diindolylmethane/comment-page-1/#comment-1925 JP Fri, 11 Dec 2009 17:52:50 +0000 http://www.healthyfellow.com/?p=427#comment-1925 Thanks, Liverock! I couldn't agree more with your prostate observation. In fact, the vast majority of clinical trials on DIM (currently underway) are studying it's effect on PCa. It's hard to objectively sort through the 13C/DIM debate. There has been one preliminary trial (in test animals) that suggests that 13C *could* have a greater impact on the processing of certain medications - via CYP1A1 and CYP1B1 expression. http://toxsci.oxfordjournals.org/cgi/content/full/74/1/10 http://www.ncbi.nlm.nih.gov/pubmed/18001209 A 2007 review concluded that I3C had more evidence to back it's use - which is does. However, the study was sponsored by a company that includes I3C (Metagenics) in their product line. A 2008 review presented a more pro-DIM take with regard to this issue. http://www.ncbi.nlm.nih.gov/pubmed/17605302 http://iv.iiarjournals.org/content/22/4/441.abstract I'm sure the results of the upcoming trials will help to better establish the relative efficacy and safety of DIM. Here's hoping for positive findings! Be well! JP Thanks, Liverock!

I couldn’t agree more with your prostate observation. In fact, the vast majority of clinical trials on DIM (currently underway) are studying it’s effect on PCa.

It’s hard to objectively sort through the 13C/DIM debate. There has been one preliminary trial (in test animals) that suggests that 13C *could* have a greater impact on the processing of certain medications – via CYP1A1 and CYP1B1 expression.

http://toxsci.oxfordjournals.org/cgi/content/full/74/1/10

http://www.ncbi.nlm.nih.gov/pubmed/18001209

A 2007 review concluded that I3C had more evidence to back it’s use – which is does. However, the study was sponsored by a company that includes I3C (Metagenics) in their product line. A 2008 review presented a more pro-DIM take with regard to this issue.

http://www.ncbi.nlm.nih.gov/pubmed/17605302

http://iv.iiarjournals.org/content/22/4/441.abstract

I’m sure the results of the upcoming trials will help to better establish the relative efficacy and safety of DIM. Here’s hoping for positive findings!

Be well!

JP

]]> By: liverock http://www.healthyfellow.com/427/dim-diindolylmethane/comment-page-1/#comment-1922 liverock Fri, 11 Dec 2009 13:07:06 +0000 http://www.healthyfellow.com/?p=427#comment-1922 I have never been able to ascertain whether I3C or DIM is better for getting safer estrogen metabolism. Maybe they are pretty much the same. Men should also strive for the sake of their prostates to get optimun estrogen levels, as high estrogen in older men appears to signal prostate problems. Thanks for the article, its a timely warning for both men and women. I have never been able to ascertain whether I3C or DIM is better for getting safer estrogen metabolism. Maybe they are pretty much the same.
Men should also strive for the sake of their prostates to get optimun estrogen levels, as high estrogen in older men appears to signal prostate problems.
Thanks for the article, its a timely warning for both men and women.

]]> By: JP http://www.healthyfellow.com/427/dim-diindolylmethane/comment-page-1/#comment-1919 JP Thu, 10 Dec 2009 16:31:14 +0000 http://www.healthyfellow.com/?p=427#comment-1919 Nina, That worries me too. But, as you know, the best antidote for worry is to be informed and proactive. You certainly embody both of those qualities! I'm sure that makes a big difference! :) I send you back greetings from the land of sunshine ... where another storm is quickly approaching! :) I love Winter! Be well! JP Nina,

That worries me too. But, as you know, the best antidote for worry is to be informed and proactive. You certainly embody both of those qualities! I’m sure that makes a big difference! :)

I send you back greetings from the land of sunshine … where another storm is quickly approaching! :) I love Winter!

Be well!

JP

]]> By: Nina K. http://www.healthyfellow.com/427/dim-diindolylmethane/comment-page-1/#comment-1915 Nina K. Thu, 10 Dec 2009 10:27:27 +0000 http://www.healthyfellow.com/?p=427#comment-1915 Thanks JP, you always reminds us women to eat healthy. i had a few breast cancer patients in earlier times as i worked as a physiotherapist and i hope and pray that i will never never get cancer. My doctor told me that hes worried about the fact that more and more very young women have malignancies. he - i too - believed that the lifestyle changes and bad nutrition are playing a major role in this context. so women, take care of you health. Greetings to "the other side" :-) Nina K. Thanks JP,

you always reminds us women to eat healthy. i had a few breast cancer patients in earlier times as i worked as a physiotherapist and i hope and pray that i will never never get cancer. My doctor told me that hes worried about the fact that more and more very young women have malignancies. he – i too – believed that the lifestyle changes and bad nutrition are playing a major role in this context.

so women, take care of you health.

Greetings to “the other side” :-)
Nina K.

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