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Hot Flashes, Influenza and Weight Loss Updates

July 14, 2010 Written by JP       [Font too small?]

There is an enormous gap between what we know and don’t know in the field of alternative and complementary medicine. Countless questions remain unanswered simply because there isn’t enough financing and resources to test in a scientific manner. That’s why it’s vitally important to put to use every last study that has been conducted. Because even the slightest of experiments can yield important clues that help bridge the knowledge gap.

Vitamin D has become one of the most revered nutrients in modern medicine. In the past few months studies published in journals such the American Journal of Clinical Nutrition, Journal of the American Geriatrics Society and PLoS One have documented Vitamin D’s ability to reduce: a) the incidence of viral infections including influenza; b) the risk of developing type 2 diabetes; c) the likelihood of falls in older men and women which result in fractures and related complications. (1,2,3)

The current interest in Vitamin D is leading researchers to study the best way to administer it. The latest example can be found in the June 2010 issue of The Medical Journal of Australia. In it, a 90 day trial involving 59 Vitamin D deficient inpatients evaluated the efficacy and safety of two different forms of Vitamin D supplementation.

  • Half of the patients received a high-dose of 50,000 IUs of Vitamin D3 for 10 days.
  • The remainder was given 3,000 IUs for 30 days followed by 1,000 IUs for 60 days.

The findings of the trial indicate that both treatments resulted in comparable increases in Vitamin D status – 55 nmol/L (high-dose) vs. 51 nmol/L (low-dose). The safety of both treatment options was also considered equivalent. Therefore, this appears to be an instance where cost and personal preference may serve as deciding factors for both patients and physicians. (4)

A recent pilot study was presented at this year’s annual meeting of the American Society of Clinical Oncology. The subject matter dealt with hot flashes that up 40% of breast cancer survivors experience. Specifically, researchers from Virginia Commonwealth University examined the applicability of magnesium supplements in this patient population. Over the course of 5 weeks, 29 breast cancer survivors who experienced at least 14 hot flashes per week were given 250 – 500 mg of magnesium oxide daily. The majority of the women (56%) found a >50% or greater reduction in their “hot flash score”. The overall conclusion was that 76% of the female participants reported a >25% decline in hot flash frequency and severity. The authors of this preliminary study stated that “Side effects and cost ($0.02/tablet) were minimal”. It’s also reassuring to know that a bigger, randomized, placebo-controlled trial is currently in the works that hopes to establish exactly how magnesium diminishes hot flashes. (5)

Vitamin D Levels Above 38 ng/ml May Reduce Viral Infection Incidence
Source: PLoS ONE 5(6): e11088. (link)

The nutritional field is fraught with conflicting advice and information about weight loss strategies. Some experts recommend that you count calories and stick to a daily caloric limit. Others want you to restrict specific dietary components such as fat and refined carbohydrates. But regardless of which approach you ultimately take, it’s probably best that you emphasize optimal protein intake as part of your game plan.

A new 12 month trial from the Department of Internal Medicine at the University of Ulm, Germany tested the relative merits of two different types of weight loss diets. Both of the diet regimens required study volunteers to eat 500 fewer calories per day than normal. However, one of the two diets assigned a higher protein intake of 1.34 grams per kilogram of body weight. This was deemed the “high-protein diet”. Option number two, the “conventional-protein diet” required protein consumption of about .8 grams per kilogram of body weight. At the end of the one year intervention, subjects following the higher protein diet had lost more fat mass and body weight than the conventional diet group. In addition, 64.5% of the high-protein volunteers exhibited improvements in criteria relating to metabolic syndrome. Only 34.8% of the conventional dieters showed the same improvements in blood sugar control and cardiovascular health markers. In the summary of the trial, the authors reveal that high protein, “nutrient-dense meal replacements” were used as part of the study protocol. This reveals yet another useful tool for dieters who wish to incorporate these protein-based supplements in weight loss programs. (6)

More often than not, major revelations in medicine and nutrition are overstated. How many times have you heard of a new cancer cure or weight loss miracle that ends up falling short? In my lifetime I’ve seen this over and over again with decidedly predictable outcomes. The somber truth is that major breakthroughs in health and science are few and far between. That’s why it’s important to remember that combating disease and maintaining wellness is a marathon not a sprint. This is precisely why we need to keep track of the details contained in preliminary experiments and studies. They’re much like tiny pieces of a gigantic jigsaw puzzle. As the individual slots are filled, the big picture begins to take form. These facts and figures may not always make headlines but they can change lives if acknowledged and judiciously applied.

Be well!

JP

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3 Comments & Updates to “Hot Flashes, Influenza and Weight Loss Updates”

  1. JP Says:

    Update 04/20/15:

    http://onlinelibrary.wiley.com/doi/10.1002/ptr.5158/full

    Phytother Res. 2014 Oct;28(10):1520-6.

    IQP-GC-101 reduces body weight and body fat mass: a randomized, double-blind, placebo-controlled study.

    IQP-GC-101 is a patented blend of the standardized extracts of Garcinia cambogia, Camellia sinensis, unroasted Coffea arabica, and Lagerstroemia speciosa. These individual ingredients of IQP-GC-101 have each shown promise in promoting weight loss; however, the efficacy of the blend has not been established. This randomized, placebo-controlled, double-blind, parallel group study conducted over 14 weeks (including a 2-week run-in phase) aimed to investigate the efficacy and safety of IQP-GC-101 in reducing body weight and body fat mass in overweight Caucasian adults. Subjects took three IQP-GC-101 or placebo tablets, twice a day, 30 min before main meals. All subjects also adhered to a 500 kcal/day energy deficit diet with 30% of energy from fat. Ninety-one overweight and mildly obese subjects (46 in the IQP-GC-101 group, 45 in the placebo group) completed the study. After 12-week intervention, IQP-GC-101 resulted in a mean (±SD) weight loss of 2.26 ± 2.37 kg compared with 0.56 ± 2.34 kg for placebo (pU  = 0.002). There was also significantly more reduction in body fat mass, waist circumference, and hip circumference in the IQP-GC-101 group. No serious adverse events were reported. The use of IQP-GC-101 has been shown to result in body weight and body fat reduction in the current study, with good tolerability.

    Be well!

    JP

  2. JP Says:

    Updated 05/11/16:

    http://www.ncbi.nlm.nih.gov/pubmed/27163520

    Menopause. 2016 May 9.

    Exercise training reduces the frequency of menopausal hot flushes by improving thermoregulatory control.

    OBJECTIVE: Postmenopausal hot flushes occur due to a reduction in estrogen production causing thermoregulatory and vascular dysfunction. Exercise training enhances thermoregulatory control of sweating, skin and brain blood flow. We aimed to determine if improving thermoregulatory control and vascular function with exercise training alleviated hot flushes.

    METHODS: Twenty-one symptomatic women completed a 7-day hot flush questionnaire and underwent brachial artery flow-mediated dilation and a cardiorespiratory fitness test. Sweat rate and skin blood flow temperature thresholds and sensitivities, and middle cerebral artery velocity (MCAv) were measured during passive heating. Women performed 16 weeks of supervised exercise training or control, and measurements were repeated.

    RESULTS: There was a greater improvement in cardiorespiratory fitness (4.45 mL/kg/min [95% CI: 1.87, 8.16]; P = 0.04) and reduced hot flush frequency (48 hot flushes/wk [39, 56]; P < 0.001) after exercise compared with control. Exercise reduced basal core temperature (0.14°C [0.01, 0.27]; P = 0.03) and increased basal MCAv (2.8 cm/s [1.0, 5.2]; P = 0.04) compared with control. Sweat rate and skin blood flow thresholds occurred approximately 0.19°C and 0.17°C earlier, alongside improved sweating sensitivity with exercise. MCAv decreased during heating (P < 0.005), but was maintained 4.5 cm/s (3.6, 5.5; P < 0.005) higher during heating after exercise compared with control (0.6 cm/s [-0.4, 1.4]).

    CONCLUSIONS: Exercise training that improves cardiorespiratory fitness reduces self-reported hot flushes. Improvements are likely mediated through greater thermoregulatory control in response to increases in core temperature and enhanced vascular function in the cutaneous and cerebral circulations.

    Be well!

    JP

  3. JP Says:

    Updated 11/02/18:

    https://www.nutritionjrnl.com/article/S0899-9007(09)00126-9/abstract

    Matern Child Nutr. 2018 Oct 31:e12746.

    High protein diet promotes body weight loss among Brazilian postpartum women.

    There is evidence in the general population that adhering to a high protein and low carbohydrate diet may help in losing weight. However, there is little evidence among postpartum women. The aim of this study is to evaluate the effect of a high protein diet on weight loss among postpartum women. A parallel-randomized controlled trial with ninety-four postpartum women was conducted in a maternity ward in Mesquita county (recruitment from February 2009 to December 2010) and in a polyclinic in Rio de Janeiro city (recruitment from December 2010 to December 2011). Women were randomized to the intervention group (IG) or control group (CG), and both groups received an isocaloric diet (1,800 kcal). Additionally, the IG received approximately 25 g of protein obtained from 125 g per week of sardine to increase daily dietary protein content and was advised to restrict carbohydrate intake. The CG received nutritional counselling to follow the national nutrition guidelines (15% protein, 60% carbohydrates and 25% lipids). A linear mixed-effects model was used to test the effect of high protein intake and macronutrient intake on weight loss during the postpartum period. Body weight decreased in the IG compared to the CG (ß=-0.325; p=0.049) among overweight and obese postpartum women. The percentage of energy intake from lipid (ß=-0.023; p=0.050) was negatively associated with body weight, and carbohydrate intake (ß=0.020; p=0.026) was positively associated with body weight over time among all women. Protein intake and lower carbohydrate intake may be used as a dietary strategy to improve body weight loss during the postpartum period.

    Be well!

    JP

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