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Hemp Seed Questions

August 18, 2010 Written by JP    [Font too small?]

The history of hemp products in the natural health industry has been one largely dominated by uncertainty. So it didn’t surprise me when a client recently asked me about them. I offered a brief summary and my best opinion. Needless to say, it differed from what he had previously been told. This is a common occurrence in my chosen field. For every health topic, there are numerous opinions. Some are generated by the conventional medical establishment. Others are promoted by the makers of hemp products, the media and health food store employees. The likelihood that all of these disparate sources will agree on anything is infinitesimal.

Simply adding another opinion to the hemp product debate is rather pointless. That is unless it is backed by transparent reasoning. Today I’ll offer my two cents about hempseed oil and protein. But what will differentiate it from most other commentary is that I’ll use published scientific studies to inform my point of view.

The controversy about hemp being the same as marijuana is mostly a relic of the past. Hemp and marijuana are sourced from different members of Cannibus genus – hemp (Sativa) and marijuana (Indica). Hemp is now widely available as a dietary supplement because of its nutrient density. Hempseeds, which are technically nuts, contain approximately 30% fat and 25% protein. Its fatty acid composition is considered highly desirable because it’s comprised of over 80% polyunsaturated fats. But what really sets hempseeds apart from most other nuts and seeds is that they present an omega-3/omega-6 ratio of approximately 1:3. This is believed to be more in line with the fatty acid make up of many traditional diets. The seeds of hemp also possess a fairly rare fatty acid known as GLA or gamma-linolenic acid which is documented as having anti-inflammatory properties. (1)

The unique components of hempseeds have compelled some researchers to investigate their health potential in both animal and human models. The most recent scientific intervention trial involved New Zealand white rabbits. The test animals were fed one of 6 diets: 1) a regular control diet; 2) control diet + 10% hempseeds; 3) control diet + defatted hempseeds; 4) control diet + .5% cholesterol; 5) control diet + .5% cholesterol + 10% hempseeds; 6) control diet + 5% coconut oil. Over the course of 8 weeks, blood tests were performed which measured cholesterol, platelet aggregation (a measure of blood clotting) and triglycerides. It was noted that the cholesterol-enriched diets lead to increased platelet aggregation. However, the addition of hempseeds to the cholesterol-rich diet nullified this effect. This is relevant because excessive platelet aggregation can increase the risk of heart attacks and strokes. (2)

I wish I could tell you that all of the studies inspire the same level of confidence about hempseeds. Unfortunately, they do not. A case in point is a human study from the February 2008 issue of the Journal of the American College of Nutrition. A total of 86 men and women took part in a 12 week double-blinded, placebo controlled trial testing the effects of fish oil, flaxseed oil and hempseed oil. Researchers from Manitoba, Canada verified that each oil was absorbed based on changes in blood levels of fatty acids in all of the study volunteers. The surprising finding was that none of the oils provoked any significant changes in circulatory factors, inflammatory markers or lipid levels. However, in fairness, it’s possible that the low dosage used (2 grams/day) was insufficient. (3)

Another human study from December 2006 compared the relative effects of flaxseed and hempseed oil on blood sugar, cholesterol, insulin and triglyceride levels in a group of 14 healthy men and women. This was a crossover trial wherein the subjects were given flax oil for 4 weeks, followed by a 4 break or washout period and then a 4 week trial with hemp oil. This time, the dosage used was considerably higher 30 ml or 30 grams/day. The hempseed oil “resulted in a lower total-to-HDL cholesterol ratio” compared to flax oil. A lower total/HDL cholesterol ratio is thought to reduce the risk of heart disease. (4)

Two animal studies from 2006 and 2007 also yielded mixed results while examining the effects of hempseed intake on “cardiac ischemia-reperfusion injury” – heart damage caused by an absence of blood flow. One of the experiments found that the addition of 10% hempseeds to the diets of rats provided significant cardioprotective effects. But, the authors of the 2006 trial came to a decidedly different conclusion: “The present study does not support the use of dietary hempseed to protect the heart during ischemic insult”. (5,6)

As far as clinical studies are concerned, the only remaining trial to review comes courtesy of the April 2005 issue of the Journal of Dermatological Treatment. In it, hempseed oil was compared to olive oil in 20-week randomized, single-blind crossover study in patients with atopic dermatitis. Those using hemp oil showed evidence of a reduction in dermal medication use, itchiness and skin dryness. The scientists conducting the study also documented a dramatic gain in select plasma fatty acids (alpha-linolenic acid, gamma-linolenic acid and lenoleic acid). They theorized that the hempseed oil corrected a pre-existing imbalance relating to polyunsaturated fatty acids. (7)

Omega-3 & Omega-6 Fatty Acids in Fish, Flax and Hemp Oil

Subject group DHA n-3 (mg) EPA n-3 (mg) ALA n-3 (mg) LA n-6 (mg) GLA n-6 (mg) n-6 (mg) n-3 (mg) n-6:n-3
Fish oil 121 176 6 13 2 15 303 0.05:1
Flaxseed oil 0 0 511 140 9 149 511 0.3:1
Hempseed oil 0 0 186 572 26 598 186 3:1
Source: J Am Coll Nutr. 2008 Feb;27(1):51-8. (link)

The sometimes hyperbolic claims made about hempseed oil far out distance the number of studies available to support them. The same is even more true in the case of hempseed protein. There has yet to be a published trial in humans utilizing hemp protein isolate (HPI). The best data we have to go on comes from a laboratory analysis published in the November 2006 edition of the Journal of Agricultural Food Chemistry. The primary conclusions found were: a) HPI has a comparable amino acid profile as soy protein isolate (SPI); b) it’s lacking in lysine and sulfur-containing amino acids, but is an otherwise sufficient protein source; c) it “can be used as a valuable source of nutrition for infants and children, but has poor functional properties when compared to SPI”. (8)

Animal studies have generally found hemp seeds to be a fine source of nutrition. If these results are translatable to humans, then it’s possible that hemp seeds could be relied upon to alleviate fatigue, promote healthy immune function and support overall health safely. But only further trials in humans can adequately answer that question. At present, I’m unaware of any major studies in this category that are planned or in progress. (9,10)

One pertinent issue that appears to be resolved is the likelihood of testing positive for marijuana while using hempseed supplements. This was a real concern in the 1990s. At that time, several scientific inquiries did indeed find unacceptably high levels of cannabinoids in commercially available products. However, recent changes in the manufacturing process and quality control measures have long since overcome this major hurdle. A newer set of published studies attest to this fact. This is also a major selling point that virtually all hemp products distributors now stand behind. No company wants to be sued as a result of an undeserved positive result during a workplace drug screening. (11,12,13,14,15,16,17,18,19)

So what’s my overall verdict on hempseed oil and protein? I wouldn’t discourage most people from trying either of them out. You see, I’m not at all convinced that they’re bad products. But I wouldn’t recommend them unless there was a good reason to do so. For example, if someone was looking for a good source of GLA or omega-3 fatty acids, I’d prefer to point them in the direction of blackcurrant seed oil, evening primrose oil, fish oil or krill oil first. The same goes for protein sources. I feel more confident recommending organic brown rice protein, egg white protein or whey protein as opposed to hemp protein isolate. The bottom line is that I’m not yet sold on the rather scant amount of research on hemp as a food source. I feel justified in this position knowing that a current summary in the April 2010 issue of the journal Nutrition and Metabolism came to a similar conclusion. Having said that, if you’ve tried hempseed oil and/or hempseed protein isolate and you think my P.O.V. is off base or “on point”, please let me know. I’m always hungry for more knowledge and I’d love to hear what you have to say. (20)

Be well!


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Posted in Heart Health, Nutritional Supplements

16 Comments & Updates to “Hemp Seed Questions”

  1. Mark Says:

    Excellent article

  2. anci Says:

    Your blog is very interesting, gives me inspiration

  3. JP Says:

    Thank you, Mark! 🙂

    Be well!


  4. JP Says:

    Thank you, Anci. I’m happy to hear it! 🙂

    Be well!


  5. Nina K. Says:

    Hello JP 🙂

    i can really recommend hempseed oil for salat. i buy it at a small local organic producer, fresh pressed. Tastes very nutty♥ it’s very green ;-), but the smell is quite different, a little bit like hay?? But the taste is really good. Give it a try 🙂 you don’t become high 😉

    Your friend from the far side
    Nina K.

  6. JP Says:

    Ha! Good to know! 😉

    I’ve never used hemp oil in salad dressing but have tried it in other forms. Hemp protein too. The latter can be very rich in fiber.

    Might you have a recipe to share for a hemp seed oil dressing?

    Be well!


  7. Nina K. Says:

    Good Morning, JP ☼

    you can use it instead of olive oil, make your fav. vinigrette with it, i combine it with sherry vinegar or condimento balsamico bianco or balsamico. depends on the type of salad. try the taste of the oil pure and then im sure you know how to combine 😉

    here one of my faves:
    beetrot and lamb’s lettuche salad with rostet nuts ( i mean this one: http://xlurl.de/CWT4DD and this: http://xlurl.de/BryB6b)

    make a dressing with sherry vinegar, herb salt, pepper and what ever you like. Tastes great with walnuts or roasted almonds and even with bacon (then use less salt 🙂 )and sprouts (broccolisprouts, lentilsprouts etc.).

    My oil : vinegar ratio isof 2:1 (2 oil : 1 vinegar).

    The next time i take a pic of it 😉

    Guten Appetit 🙂
    Nina K.

  8. Nina K. Says:

    wow second link doesn’t work:

    here you go: http://www.fruechteadam.com/img/Rotebete.jpg

    my salad looks very similar to this one:


    Guten Appetit ☺

  9. JP Says:

    Many thanks, Nina! That looks and sounds great! 🙂

    Be well!


  10. Igor Says:

    Several years ago I bought a couple of bottles of virgin hemp oil from a lady at a farmer’s market who was touting it as the perfect oil. Not only did the stuff taste awful, but it made me gain weight and gave me digestive problems.

    I’ll stick to time-tested butter and olive oil, thank you very much.

  11. Mary Says:

    Where hemp is known for its exceptional ability to decontaminate polluted soils, by absorbing heavy metals and other toxins into the plant, I wonder about the safety of the plant as a food product. Although food crops are not grown on highly contaminated soil, all soil has some level of lead, arsenic, mercury, etc., and hemp is a sponge for toxins. Are hemp products tested for toxins, or are the products purified in some way? Is this information available to consumers?

  12. JP Says:


    This is a good question that could and should be posed to hemp supplement manufacturers. A cursory search on the ‘net didn’t turn up much re: hemp products and heavy metal content. A recent ConsumerLab review tested various protein powders – but not hemp seed protein. It’s interesting to note that in that round of testing, only rice-based proteins were found to contain traces of heavy metals (lead).

    Be well!


  13. mike b Says:

    I was wondering whether you have reviewed any of the nutritional data for spirulina or chlorella. They are touted as superfoods, and the best sources of protein and other nutrients.

    Overall, I would certainly opt for either hemp or spirulina over animal protein. Even whey protein is suspect because of residual synthetic hormones fed to cows to stimulate milk production.

    What would you consider the best plant protein?

    Thanks. Great info here! We need more data!!!

  14. JP Says:


    There’s very limited data (mostly in animal models of nutrition) about the protein quality of microalgae such as chlorella and spirulina.

    Here’s a recent column I wrote about chlorella and spirulina and several links to studies that have examined the use of microalgae as a protein source:






    If you’re looking for a plant-based protein powder, I’d consider some of the sprouted brown rice and legume products that are currently on the market.

    Hemp is probably fine too but there’s scant information about how well it stacks up to other protein sources.

    One note of precaution: some brown rice protein powders contain unacceptably high concentrations of lead – according to ConsumerLab test results. If you use such products, check with the manufacturer(s) to verify that they screen for this potential hazard.

    Some info. on hemp seed protein: https://www.healthyfellow.com/757/best-of-hemp-seed-questions/

    Be well!


  15. Rob Says:

    If youre relying on Hemp and Spirulina, even Chlorella, as your protien sources you are doing youself a disservice

  16. JP Says:

    Update: Shelled hemp seeds are an excellent source of magnesium – about 45% of the RDA per ounce.


    Be well!


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